Two Popular Diabetes Drugs Outperformed Others in a New Study
Two of the most popular diabetes drugs have been found to work better than one another. A recent study of more than 5,000 patients with type 2 diabetes found that two injectable medications kept more patients in the recommended blood sugar range for five years. Most study participants were not able to stay in this range for long.
Metformin
Metformin and insulin outperformed other drugs in a study that looked at the comparative effectiveness of these drugs. When combined with diet and exercise, metformin is a low-cost, widely available, and effective stand-alone diabetes drug. It reduces the risk of heart disease by 30 to 40%.
Metformin and insulin are the old standbys of diabetes drugs. These drugs help people with type 2 diabetes control their blood sugar levels. A new study, conducted by the National Institutes of Health, pitted several drugs against one another. It found that metformin and insulin were more effective at controlling blood sugar over a period of time than glimepiride and insulin glargine.
The study found that metformin reduced the number of pathological microglia and transformed them into non-inflammatory cells. It also inhibited mTOR signaling, which regulates energy balance in the cell.
Insulin glargine
Insulin glargine and insulin-like peptides (INS) are a new type of diabetes medication that have shown impressive results in a study conducted in New Zealand. Both drugs are classified as biologic medications, which means that they are created from living organisms. There are also biosimilar insulin glargine products on the market, which work in the same way as the original insulin.
Insulin glargine and insulin-like peptides are long-acting, synthetic versions of human insulin. They help the body move sugar from the bloodstream into cells, where it is stored as glycogen. In addition, they inhibit the liver from producing more sugar.
New research has shown that insulin glargine and insulin-like peptides outperformed other types of diabetes drugs in a clinical trial. The study compared four diabetes drugs approved by the U.S. Food and Drug Administration and three other drugs. The study found that insulin glargine outperformed the other two drugs by a modest margin.
Liraglutide
Liraglutide, a type 2 diabetes drug, has shown better weight loss than other diabetes drugs, including glipizide and semaglutide. Compared with glipizide, the liraglutide-treated group experienced a 7.8 percent reduction in body weight, which was comparable to other studies of similar length. By contrast, semaglutide-treated participants saw only a five to ten percent reduction in weight, which was significantly lower than the other two groups.
The study found that insulin glargine, glimepiride, and liraglutide all had similar blood glucose-lowering effects, but liraglutide was more effective overall. The study was conducted across 5047 people with type 2 diabetes in five-year periods, and the results were analyzed to determine which drug had the best effect on patients with diabetes.
The results of the trial were published in the New England Journal of Medicine. The study focused on two outcomes: blood glucose control and cardiovascular disease. In particular, people taking liraglutide had lower HbA1c levels and a lower risk of cardiovascular disease.
